Categoría: Swine

DIFFERENTIAL 1 ACTION OF TGR5 AGONISTS ON GLP-2 SECRETION AND PROMOTION OF INTESTINAL ADAPTATION IN PIGLET SHORT BOWEL MODEL

Enteroendocrine L cells and GLP-2 secretion are activated in the intestinal adaptation process following bowel resection in short bowel patients. We hypothesized that enteral activation of Takeda G-protein-coupled receptor 5 (TGR5) expressed in enteroendocrine L cells could augment endogenous GLP-2 secretion and the intestinal adaptation response. Our aim was to…

RESPONSE OF PIGLETS TO A BITTER TASTE AND ITS EFFECT ON FEED INTAKE

Bitter taste perception acts as a signal to the central nervous system to warn animals against consuming potentially toxic substances. When bitter compounds activate bitter taste receptors, a signal reaches the brain that triggers an aversive response and activation of anorexic signals, hence reducing feed intake. The objective of the…

ANTIMICROBIAL PROMOTION OF PIG GROWTH IS ASSOCIATED WITH TISSUE-SPECIFIC REMODELING OF BILE ACID SIGNATURE AND SIGNALING

The spread of bacterial resistance to antimicrobials (AMA) have intensified efforts to discontinue the non-therapeutic use of AMA in animal production. Finding alternatives to AMA, however, is currently encumbered by the obscure mechanism that underlies their growth-promoting action. In this report, we demonstrate that combinations of antibiotics and zinc oxide…

MINOR DIETARY SUPPLEMENTATION WITH A PROTEIN HYDROLYSATE IMPROVES ILEAL MUCOSAL INTEGRITY AND NUTRIENT TRANSPORT, POTENTIALLY MEDIATED BY INCREASED GLP-1/GLP-2 SECRETION

Gastrointestinal functionality is regulated by a complex network of receptors exposed to the luminal environment that sense the presence of nutrients and other chemicals, triggering endocrine and neural pathways that ultimately affect physiological and metabolic responses. This is commonly referred to as “gut chemosensing”. Some of these mechanisms have started…